Phylogeography of the fungal pathogenHistoplasma capsulatum
نویسندگان
چکیده
منابع مشابه
Phylogeography of the fungal pathogen Histoplasma capsulatum.
Until recently, Histoplasma capsulatum was believed to harbour three varieties, var. capsulatum (chiefly a New World human pathogen), var. duboisii (an African human pathogen) and var. farciminosum (an Old World horse pathogen), which varied in clinical manifestations and geographical distribution. We analysed the phylogenetic relationships of 137 individuals representing the three varieties fr...
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Eng1 and Exg8 Are the Major β-Glucanases Secreted by the Fungal Pathogen Histoplasma capsulatum.
Fungal cell walls contain β-glucan polysaccharides that stimulate immune responses when recognized by host immune cells. The fungal pathogen Histoplasma capsulatum minimizes detection of β-glucan by host cells through at least two mechanisms: concealment of β-glucans beneath α-glucans and enzymatic removal of any exposed β-glucan polysaccharides by the secreted glucanase Eng1. Histoplasma yeast...
متن کاملSecreted dipeptidyl peptidase IV activity in the dimorphic fungal pathogen Histoplasma capsulatum.
Dipeptidyl peptidase type IV (DppIV) enzymes are broadly distributed phylogenetically and display diverse functions, including intercellular signaling, immunomodulation, protein maturation and processing, metabolism, and nutrient acquisition. We identified a secreted proteolytic activity in Histoplasma capsulatum effective toward DppIV-specific substrates. In order to determine the gene(s) that...
متن کاملIdentifying phase-specific genes in the fungal pathogen Histoplasma capsulatum using a genomic shotgun microarray.
A fundamental feature of the fungal pathogen Histoplasma capsulatum is its ability to shift from a mycelial phase in the soil to a yeast phase in its human host. Each form plays a critical role in infection and disease, but little is understood about how these two morphologic phases are established and maintained. To identify phase-regulated genes of H. capsulatum, we carried out expression ana...
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ژورنال
عنوان ژورنال: Molecular Ecology
سال: 2003
ISSN: 0962-1083,1365-294X
DOI: 10.1046/j.1365-294x.2003.01995.x